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目的探讨根除幽门螺杆菌对长期联用阿司匹林和氯吡格雷者上消化道再出血发生率的影响。方法以2010年2月至2013年1月封丘县人民医院收治的109例长期联用阿司匹林和氯吡格雷合并上消化道出血患者为研究对象,所有患者进行胃镜检查及尿素酶试验,两项结果均为阳性则为Hp阳性。其中68例显示为阳性(阳性组),其余41例显示为阴性(阴性组),依据随机数字表法将阳性组分为治疗组和对照组。比较阳性组和阴性组、治疗组和干预组的再出血、临床表现、病因。结果阴性组再出血情况显著优于阳性组,治疗组再出血情况显著优于对照组,差异有统计学意义(P<0.05)。结论根除幽门螺杆菌能够有效降低长期联用阿司匹林和氯吡格雷者上消化道再出血的发生率。
Objective To investigate the effect of Helicobacter pylori eradication on the incidence of upper gastrointestinal rebleeding in long-term aspirin and clopidogrel. Methods A total of 109 patients with long-term aspirin and clopidogrel combined with upper gastrointestinal bleeding admitted to Fengqiu County People’s Hospital from February 2010 to January 2013 were enrolled. All patients underwent gastroscopy and urease tests. The results were positive for Hp positive. Among them, 68 cases showed positive (positive group), while the remaining 41 cases showed negative (negative group). According to the random number table method, the positive components were divided into treatment group and control group. Compare the positive group and negative group, the treatment group and the intervention group of rebleeding, clinical manifestations, etiology. Results The rebleeding in the negative group was significantly better than that in the positive group. The rebleeding in the treatment group was significantly better than that in the control group (P <0.05). Conclusions Eradication of Helicobacter pylori can effectively reduce the incidence of upper gastrointestinal rebleeding in long-term use of aspirin and clopidogrel.