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HSP6 0是一类进化上高度保守的蛋白质家族。生理状态时协助多肽或蛋白质的正确转位、折叠和装配 ,起“分子伴侣”的作用 ;在应激状态下 ,HSP6 0过表达或异位表达 ,作为一种自身抗原被免疫系统识别 ,诱发机体的保护性免疫应答 ,也可作为一种信号分子 ,在信号转导中发挥作用。近年来研究证实 HSP6 0在自身免疫性疾病、传染病、动脉粥样硬化及慢性感染的发病中均发挥重要的作用
HSP60 is a family of highly conserved proteins that are evolutionarily conserved. Physiological state to help the correct translocation, folding and assembly of peptides or proteins, play a “chaperone” role; under stress, HSP60 overexpression or ectopic expression, as an autoantigen recognized by the immune system, induced The body’s protective immune response, but also as a signaling molecule, plays a role in signal transduction. In recent years, studies have confirmed that HSP60 plays an important role in the pathogenesis of autoimmune diseases, infectious diseases, atherosclerosis and chronic infections