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药物的代谢动力学各环节均受遗传因素影响。特别是在肝药酶(N-乙酰转移酶)催化下,有些药物可与乙酰基结合呈乙酰化而失活.但不同个体因先天遗传基因的差别与种族或环境影响,对同一药物的乙酰化能力和速度不完全相同,可有快型和慢型之分。快型的血药浓度较低而慢型的血药浓度往往偏高,这可直接影响药物疗效及其毒性反应。如50年代已用的肼苯哒嗪,对慢型乙酰化患者的血药浓度较快型患者要高2倍(只需小
Metabolic kinetics of drugs are affected by genetic factors in all aspects. Especially in the liver enzyme (N-acetyltransferase) catalysis, some drugs can be acetylated acetylation and inactivation.However, different individuals due to genetic and genetic differences in race or the environment, the same drug acetyl Ability and speed are not exactly the same, there may be fast and slow type of points. Fast plasma concentrations of lower and slower blood concentration is often high, which can directly affect the drug efficacy and toxicity. Hydralazine, already used in the 1950s, was 2 times more potent for patients with slower acetylation in the plasma (only smaller