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本文报告了可可色素的急性、亚急性毒性试验结果。LD50为5800mg/kg时属实际无毒,初步建议ADI可暂订为1mg/kg。文章提出了对低毒性受试物质应分次给药,以每日总剂量计算LD50的意见。另亚急性毒性试验观察到对血脂升高影响明显,其原因尚待进一步探讨。
This article reports the results of acute and subacute toxicity tests of cocoa pigments. LD50 is 5800mg / kg is actually non-toxic, initially proposed ADI can be temporarily set at 1mg / kg. The article proposed the low toxicity of the test substance should be administered in divided doses, the total daily dose of LD50 calculation. Another sub-acute toxicity test observed significant effect on elevated blood lipids, the reason remains to be further explored.