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Lau LC等人进行了一项研究,西地那非,他达拉非,伐地那非和维拉帕米诱导经去甲肾上腺素预收缩的兔阴茎海绵体平滑肌松弛,且具有浓度依赖性。20mM时最大松弛程度(%)分别是(61.4±6.9)、(32. 4±5.4)、(100.0±5.5)和(86.6±5.1)(n=5)。使用N-L-硝基精氨酸或鸟苷酸环化酶抑制剂,不含腺苷酸环化酶抑制剂的ODQ,以及MDL12330A预孵育的海绵体平滑肌,3种磷酸二酯酶抑制剂松弛肌肉作用
In a study by Lau LC et al., Sildenafil, tadalafil, vardenafil, and verapamil induced relaxation of the smooth muscle of rabbit corpus cavernosum precontracted with norepinephrine in a concentration-dependent manner . The maximum degree of relaxation (%) at 20 mM was (61.4 ± 6.9), (32.4 ± 5.4), (100.0 ± 5.5) and (86.6 ± 5.1), respectively (n = 5). Using NL-nitroarginine or guanylate cyclase inhibitors, ODQ without adenylate cyclase inhibitor, and sponge smooth muscle pre-incubated with MDL12330A, three phosphodiesterase inhibitors relax muscle effect