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目的探讨恶性肿瘤患者血清叶酸(FA)、维生素B12(VitB12)水平的变化及临床意义。方法应用化学发光免疫分析法对23例恶性肿瘤无贫血患者进行了血清FA、VitB12水平检测,并与27例癌性贫血患者及20例正常对照组作比较。结果肿瘤患者血清FA水平显著低于对照组(P<0.05),VitB12水平与对照组比较差异无统计学意义。结论恶性肿瘤患者血清FA水平的变化对其病情和预后判断有重要的临床意义,而VitB12的测定似乎临床价值不大。
Objective To investigate the changes and clinical significance of serum folic acid (FA) and vitamin B12 (VitB12) in patients with malignant tumor. Methods Serum FA and VitB12 levels were measured in 23 patients with anemia without malignancy by chemiluminescence immunoassay and compared with 27 patients with cancerous anemia and 20 normal controls. Results The level of serum FA in tumor patients was significantly lower than that in control group (P <0.05). There was no significant difference in VitB12 level between the two groups. Conclusion The changes of serum FA levels in patients with malignant tumor have important clinical significance in the judgment of their disease and prognosis. The measurement of VitB12 seems to be of little clinical value.