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目的 探讨急性大面积肺栓塞的治疗经验。方法 应用大剂量尿激酶 (2× 10 4U/kg) 30min内快速滴入溶栓治疗急性大面积肺栓塞患者 4例 ,观察疗效并监测SaO2 和PaO2 的变化。结果 4例患者均抢救成功 ,溶栓治疗后 30min 2例患者SaO2 即有改善 ;1h后 4例患者SaO2 和PaO2 均有明显改善 ;2h后已基本恢复正常 ,4h后稳定于正常水平。结论 大剂量尿激酶快速滴入 ,能快速有效溶栓 ,是救治急性大面积肺栓塞的有效措施。
Objective To investigate the treatment of acute large area pulmonary embolism. Methods Four cases of acute massive pulmonary embolism were treated with rapid infusion of thrombolysis within 30 min with high dose of urokinase (2 × 10 4 U / kg). The curative effect was observed and the changes of SaO2 and PaO2 were monitored. Results All 4 patients were rescued successfully. SaO2 was improved in 2 patients 30 min after thrombolytic therapy. SaO2 and PaO2 were significantly improved in 4 patients after 1 h and returned to normal after 2 h and stabilized at normal level after 4 h. Conclusion Rapid infusion of high-dose urokinase can rapidly and effectively thrombolysis, is an effective measure to treat acute large-area pulmonary embolism.