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目的:确定清血八味颗粒质量标准。方法:通过薄层鉴别方法对处方中牛黄、紫草进行定性鉴别。运用高效液相色谱法对栀子中的栀子苷进行含量测定。结果:薄层色谱斑点清晰,阴性对照无干扰。含量测定栀子苷量在0.128-0.640μg之间有良好的线性关系,相关系数r=0.9999。回收率为99.02%,RSD=1.8%(n=5)。结论:所建立的方法可靠,能准确地进行定性、定量检测,可用于该制剂的质量控制。
Objective: To determine the quality standards of Qingwei Bawei granules. Methods: Identification of bezoar and lithospermum in prescription by TLC method. The content of geniposide in gardenia was determined by high performance liquid chromatography. Results: Thin-layer chromatography spots clear, negative control without interference. Determination of content of geniposide 0.128-0.640μg in a good linear relationship between the correlation coefficient r = 0.9999. The recovery was 99.02% with RSD = 1.8% (n = 5). Conclusion: The established method is reliable, can be accurately qualitative and quantitative detection, can be used for the quality control of the preparation.