目的：为了解颈内静脉结扎对颅内组织器官的影响及其时间和范围，探索颈内静脉结扎后并发症发生的机理，从而指导颈内静脉结扎的围手术期处理．方法：采用新西兰大白兔作为实验对象，设立空白对照、单纯左侧及右侧和双侧颈内静脉结扎４组，于术前及术后４８小时内监测颅内压变化及１周后脑组织病理改变．结果：对照组手术前后颅内压无明显改变；单侧颈内静脉结扎后颅内压均有上升，在术后１小时达高峰并持续至术后４小时开始下降（Ｐ＜０．０５），术后４８小时恢复至术前水平；而双侧颈内静脉结扎者术后颅内压则显著上升，术后 ２，小时达高峰并持续至４８小时还高于术前（Ｐ＜０．０５）． １周后脑组织病理检查发现对照组及单侧颈内静脉结扎者无明显改变；双侧颈内静脉结扎者有颅内广泛胶质细胞增生．结论：单侧颈内静脉结扎后颅内压均有一过性上升，双侧颈内静脉结扎后颅内压上升显著且持续时间长．建议一般不要结扎双侧颈内静脉，颈内静脉结扎后４８小时内应严密观察病情，必要时测定颅内压及血液粘度并使用降低颅内压及血液粘度的药物． OBJECTIVE: To understand the effect of internal jugular vein ligation on intracranial tissues and organs, its time and range, and explore the mechanism of complications after ligation of internal jugular vein in order to guide the perioperative management of ligation of internal jugular vein. Methods: New Zealand white rabbits were used as experimental subjects. Blank control group was established. Left and right sides and bilateral jugular vein ligature were performed in 4 groups. Changes of intracranial pressure and intracranial pressure were observed within 48 hours before and after operation. change. Results: The intracranial pressure had no significant change in the control group before and after surgery. The intracranial pressure increased after ligation of the unilateral internal jugular vein and peaked at 1 hour and continued to decrease 4 hours after the operation (P <0.05) , And returned to the preoperative level at 48 hours after operation. The intracranial pressure increased significantly after bilateral internal jugular vein occlusion, reaching the peak at 2 hours and continuing up to 48 hours before surgery (P <0. 05). One week later, no significant changes were found in the control group and the unilateral jugular vein ligation in the pathological examination of brain tissue. The bilateral jugular vein ligation had extensive intracranial glial proliferation. CONCLUSION: All intracranial pressure has increased transiently after ligation of unilateral internal jugular vein. The intracranial pressure increases significantly after ligation of bilateral internal jugular vein for a long time. It is recommended not to ligate the bilateral internal jugular vein in general, and the condition should be closely observed within 48 hours after the ligation of the internal jugular vein. If necessary, determine the intracranial pressure and blood viscosity and use drugs to reduce intracranial pressure and blood viscosity.