论文部分内容阅读
目的探讨儿童异基因造血干细胞移植(Allo-HSCT)后使用伊曲康唑注射液预防早期真菌感染的疗效,并评价血浆真菌(1-3)-β-D-葡聚糖检测(G试验)的临床诊断价值。方法回顾性调查分析2008年3月~2011年2月南方医院儿科145例异基因造血干细胞移植术后早期真菌感染的发生情况。结果伊曲康唑注射液预防组及口服抗真菌药预防组的早期真菌感染率分别为5.50%和22.22%,两组早期死亡率分别为1.83%和11.11%,差异均有统计学意义(P<0.05);伊曲康唑注射液副作用少。112例患儿进行了G试验,73例患儿结果阳性,其中3例为真菌感染病例;39例患儿结果阴性,其中1例为真菌感染病例;G试验对诊断真菌感染无统计学意义(P>0.05)。结论伊曲康唑注射液能有效、安全地预防儿童allo-HSCT术后早期真菌感染。G试验在儿童allo-HSCT术后早期合并真菌感染诊断方面的应用价值有待进一步探讨。
Objective To investigate the efficacy of itraconazole injection in the prevention of early fungal infection after allogeneic hematopoietic stem cell transplantation (Allo-HSCT) in children, and to evaluate the effect of plasma fungal (1-3) -β-D-glucan test (G test) The clinical diagnostic value. Methods A retrospective investigation was conducted to analyze the incidence of early fungal infections in 145 pediatric patients with allogeneic hematopoietic stem cell transplantation in Nanfang Hospital from March 2008 to February 2011. Results The early fungal infection rates of itraconazole injection prevention group and oral antifungal drug prevention group were 5.50% and 22.22%, respectively. The early mortality rates in both groups were 1.83% and 11.11%, respectively, and the differences were statistically significant (P <0.05); Itraconazole injection side effects. G tests were performed in 112 children and 73 children were positive, of which 3 were fungal infections; 39 were negative, of which 1 was a case of fungal infection; the G test was not statistically significant for the diagnosis of fungal infections P> 0.05). Conclusion Itraconazole injection can effectively and safely prevent early childhood fungal infection after allo-HSCT in children. G test in children with early diagnosis of allo-HSCT complicated with fungal infection in the application of the value to be further explored.