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目的评价左炔诺孕酮宫内缓释系统(LNG-IUS)治疗子宫内膜异位症(EM)的长期安全性。方法 49例EM患者用LNG-IUS治疗,于治疗前及治疗后6,12,36,60个月,比较患者的痤疮、面部色素沉着、乳房胀痛、体毛、生活质量评分和体重等变化。结果与治疗前相比,49例患者在随访各时间点,观察体毛评分、面部色素沉着评分与体重,差异均无统计学意义(均P>0.05);生活质量和乳房胀痛评分均显著好转,差异有统计学意义(均P<0.05)。与治疗前相比,痤疮评分在治疗6个月后差异无统计学意义(P>0.05),但治疗12,36,60个月后均明显降低(均P<0.05)。结论 LNG-IUS是一种可长期治疗EM的安全性较高的治疗方法。
Objective To evaluate the long-term safety of levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of endometriosis (EM). Methods 49 patients with EM were treated with LNG-IUS. The changes of acne, facial pigmentation, breast pain, body hair, quality of life score and body weight were compared before and 6,12,36 and 60 months after treatment. Results Compared with those before treatment, 49 patients showed no significant difference in body hair score, facial pigmentation score and body weight at all time points (all P> 0.05). Quality of life and breast tenderness scores were significantly improved , The difference was statistically significant (both P <0.05). Compared with before treatment, acne score was not significantly different after 6 months of treatment (P> 0.05), but after 12, 36 and 60 months of treatment, the acne score was significantly lower (all P <0.05). Conclusion LNG-IUS is a safe, long-term therapy for EM.