新生儿缺氧-缺血性脑病(HIE)常致脑瘫、智力迟钝、无学习能力及癫痫等慢性残疾状态。据估计,每千个足月新生儿中有2～4个于分娩前或分娩时发生窒息,早产儿发病率则近60%。本病按新生儿胎龄不同,病死率可达10～60%不等。25%以上的幸存者可遗留神经 Neonatal hypoxic-ischemic encephalopathy (HIE) often causes chronic disability such as cerebral palsy, mental retardation, non-learning ability and epilepsy. It is estimated that between 2 and 4 neonates per 1,000 full-term babies are asphyxiated before or during childbirth, with an incidence of nearly 60% of premature babies. The disease according to different gestational age newborns, case fatality rate of up to 10 ~ 60%. More than 25% of survivors can leave nerves