论文部分内容阅读
抗菌素的研究为天然产物化学提供了化学合成、生物合成以及具有生物活性的新结构类型的物质。作者等于1965年着手从微生物中筛选酶的抑制剂,为发现新药开辟了新领域。已分离得到的酶抑制剂有抑制胰蛋白酶(Trypsin)和木瓜蛋白酶(Papain)的leupeptin和antipain;抑制糜蛋白酶(Chymotrypsin)的chymostatin;抑制胃蛋白酶(Pepsin)的pepstatin;抑制唾液酸酶(Sialidases)的panosialin;抑制酪氨酸水解酶(Tyrosine hydroxylase)的oudenone;抑制多巴胺β-水解酶(Dopamineβ-hydroxylase)的dopastin;抑制酪氨酸水解酶和多巴胺β-水解酶的aquayamycin和chrothiomycin。这些化合物的大多数已完成结构鉴定和合成
Antibiotic research provides natural product chemistry with chemical synthesis, biosynthesis, and a new class of biologically active substances. The author is equal to the 1965 screening of enzymes from microorganisms inhibitors, opened up new areas for the discovery of new drugs. Enzyme inhibitors that have been isolated are leupeptin and antipain that inhibit Trypsin and papain; chymostatin that inhibits chymotrypsin; pepstatin that inhibits pepsin; Sialidases that inhibit sialidase; Of panosialin; oudenone that inhibits tyrosine hydroxylase; dopastin that inhibits dopamineβ-hydroxylase; and aquayamycin and chrothiomycin that inhibit tyrosine and dopamine β-hydrolases. Most of these compounds have been structurally characterized and synthesized