近3～4年来,白血病染色体异常概念发生很大变化。过去认为急性白血病染色体畸变无特异性,然而目前已发现数种共同性染色体异常。过去认为出现异常的频率为50%左右,而Yunis等采用新的分染法发现大部分病例出现异常改变。过去一向认为Ph~Ⅰ是慢粒所特有,但自从发现Ph~Ⅰ染色体也见于淋巴细胞性白血病和骨髓瘤等症以来,对Ph~Ⅰ在表现型上的特异性问题已开始发生怀疑。本文以作者的研究工作为中心,概述白血病染色体的现状。 Nearly 3 to 4 years, leukemia chromosomal abnormalities have undergone great changes. In the past that acute leukemia chromosome aberrations non-specific, however, has found several common chromosomal abnormalities. In the past that the frequency of anomalies is about 50%, Yunis, etc. using the new method of distribution found in most cases of abnormal changes. In the past, Ph ~ I was thought to be unique to Cimicifuga, but since the discovery of Ph ~ I chromosomes also found in lymphocytic leukemia and myeloma embolism, the phenotypic specificity of Ph ~ I has begun to arise. This article focuses on the author’s research work, summarizing the status of leukemia chromosome.