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背景:近年研究证实中枢神经组织有再生能力,但损伤后修复功能较差,很多实验结果不能令人满意。既往的脑移植或脑组织移植最大的生物学障碍是移植物难以在宿主体内生存或发育,移植效果的稳定性及其功能的恢复不肯定。目的:探讨鞘内神经干细胞注射治疗脑卒中的方法,观察其疗效及副作用,以评价其安全性及可行性。设计:以患者为研究对象,前后对照的验证性研究。单位:一所市级医院神经内科和一所大学医院微生物与免疫学教研室。对象:2002-11/2003-09安阳市人民医院神经内科住院脑卒中患者26例。其中3例为急性脑出血,其余23例病程3个月～30年,平均(4.2±6.6)年;男20例,女6例;年龄36～72岁,平均(56.3±12.7)岁;脑梗死15例,脑出血11例;合并高血压19例,冠心病2例,糖尿病4例,高脂血症4例。干预:3例急性脑出血(出血量35～40mL)患者行微创血肿穿刺术,通过引流管将细胞悬液注射到脑损伤处;其余病例均采用鞘内注射的方法将细胞悬液注入蛛网膜下腔,通过脑脊液循环至大脑表面。术后采用物理治疗、作业治疗及语言治疗进行康复。采用欧洲卒中量表评分标准(Europeanstrokescale,ESS)、生活功能评分标准(barthelindex,BI)评价其疗效。ESS提高1分以上为有效,无提高或下降为无效。检查患者头颅CT,MRI,心电图、胸部X射线片及血?
Background: In recent years, studies have confirmed that CNS tissue has regenerative ability, but the repair function after injury is poor, and many experimental results are unsatisfactory. Previous biological transplantation of brain or brain transplantation is the biggest biological obstacle in the host is difficult to survive or develop in the host, the stability of the transplant effect and its recovery of function is not sure. Objective: To explore the method of injecting intrathecal neural stem cells for treating stroke and to observe its curative effect and side effects to evaluate its safety and feasibility. Design: A case-control study of patients. Unit: a municipal hospital neurology and a university hospital Department of Microbiology and Immunology. PARTICIPANTS: A total of 26 patients with stroke were hospitalized in Department of Neurology, Anyang People ’s Hospital from November 2002 to September 2003. Among them, 3 were acute intracerebral hemorrhage, and the remaining 23 were from 3 months to 30 years, with an average of (4.2 ± 6.6) years. There were 20 males and 6 females, ranging in age from 36 to 72 years (mean, 56.3 ± 12.7 years) 15 cases of infarction, 11 cases of cerebral hemorrhage; 19 cases of hypertension, coronary heart disease in 2 cases, 4 cases of diabetes, 4 cases of hyperlipidemia. Intervention: Three patients with acute intracerebral hemorrhage (bleeding volume 35 ~ 40mL) underwent minimally invasive hematoma puncture and the cell suspension was injected into the brain injury through a drainage tube. The remaining cases were injected intrathecally Subcaval, through the cerebrospinal fluid circulation to the brain surface. Postoperative physical therapy, occupational therapy and language therapy for rehabilitation. The European Stroke Scale (ESS) and life function score (BI) were used to evaluate the efficacy. ESS increase more than 1 point is valid, no increase or decrease is invalid. Check the patient’s head CT, MRI, ECG, chest X-ray and blood?