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目的:观察剔毒护肝方抗肝纤维化作用。方法:用鸭乙型肝炎病毒(DHBV)阳性血清反复攻击复制鸭乙型肝炎肝纤维化模型,同时用剔毒护肝方治疗,观察其对肝纤维化指标的影响。结果:剔毒护肝方能提高白蛋白和降低球蛋白含量,且有显著降低透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、肝组织羟脯氨酸(Hyp)的作用,能减轻肝脏胶原纤维增生程度。结论:剔毒护肝方具有抗肝纤维化的作用。
Objective: To observe the anti-fibrosis effect of Tiaodu Hugan Decoction. METHODS: Duck hepatitis B virus liver fibrosis model was repeatedly challenged with duck hepatitis B virus (DHBV) positive serum and treated with Tidu Hugan Recipe to observe its effect on hepatic fibrosis index. RESULTS: Tiaodu Hugan Decoction can increase albumin and decrease the content of globulin, and significantly reduce the effects of hyaluronic acid (HA), type III procollagen (PCIII) and liver tissue hydroxyproline (Hyp), and can reduce The degree of liver collagen fibrosis. Conclusion: Tidu Hugan Decoction has anti-fibrosis effect.