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结扎兔冠脉左室枝45min,再灌注180min,复制急性心肌缺血/再灌注模型,观察等容血液稀释和超氧化物歧化酶(SOD)对兔心肌缺血/再灌注损伤保护的协同作用并探讨其可能的机制。40只动物随机分为4组:Ⅰ组(对照组)、Ⅱ组(稀释组)、Ⅲ组(SOD组)和Ⅳ组(稀释+SOD组)。结果:与Ⅰ组比,Ⅱ,Ⅲ组左室收缩功能(最大收缩压、+dp/dtmax)显著改善,Ⅳ组较Ⅱ,Ⅲ组又有显著改善。与Ⅰ组梗塞面积(左室梗塞面积占左室总面积的百分比为18.1±2.3%)比,Ⅱ,Ⅲ,Ⅳ组梗塞面积显著缩小(分别为11.4±2.1%,13.8±2.2%,8.3±2.9%),Ⅳ组梗塞面积较Ⅲ组又有进一步缩小(P<0.05)。提示:等容血液稀释和SOD对兔缺血/再灌注心肌均有保护作用;两者联用可进一步改善左室收缩功能和缩小梗塞面积。
The left ventricular branches of rabbits were ligated for 45min and reperfused for 180min. The acute myocardial ischemia / reperfusion model was duplicated to observe the synergistic effect of isovolemic hemodilution and superoxide dismutase (SOD) on myocardial ischemia / reperfusion injury in rabbits And explore its possible mechanism. Forty animals were randomly divided into 4 groups: group Ⅰ (control group), group Ⅱ (dilution group), group Ⅲ (SOD group) and group Ⅳ (dilution + SOD group). Results: Compared with group Ⅰ, the systolic function (max systolic pressure, + dp / dtmax) of group Ⅱ and Ⅲ were significantly improved, and group Ⅳ and group Ⅲ were significantly improved compared with group Ⅰ. Compared with the infarction area of group Ⅰ (the percentage of left ventricular infarction area to the total left ventricular area was 18.1 ± 2.3%), infarct size in group Ⅱ, Ⅲ and Ⅳ was significantly reduced (11.4 ± 2.1% , 13.8 ± 2.2%, 8.3 ± 2.9% respectively). The infarction area in group Ⅳ was further reduced than that in group Ⅲ (P <0.05). Tip: Isotonic hemodilution and SOD on rabbit ischemia / reperfusion myocardial protective effect; the combination of the two can further improve left ventricular systolic function and reduce infarct size.