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结扎兔冠脉左室枝４５ｍｉｎ，再灌注１８０ｍｉｎ，复制急性心肌缺血／再灌注模型，观察等容血液稀释和超氧化物歧化酶（ＳＯＤ）对兔心肌缺血／再灌注损伤保护的协同作用并探讨其可能的机制。４０只动物随机分为４组：Ⅰ组（对照组）、Ⅱ组（稀释组）、Ⅲ组（ＳＯＤ组）和Ⅳ组（稀释＋ＳＯＤ组）。结果：与Ⅰ组比，Ⅱ，Ⅲ组左室收缩功能（最大收缩压、＋ｄｐ／ｄｔｍａｘ）显著改善，Ⅳ组较Ⅱ，Ⅲ组又有显著改善。与Ⅰ组梗塞面积（左室梗塞面积占左室总面积的百分比为１８．１±２．３％）比，Ⅱ，Ⅲ，Ⅳ组梗塞面积显著缩小（分别为１１．４±２．１％，１３．８±２．２％，８．３±２．９％），Ⅳ组梗塞面积较Ⅲ组又有进一步缩小（Ｐ＜０．０５）。提示：等容血液稀释和ＳＯＤ对兔缺血／再灌注心肌均有保护作用；两者联用可进一步改善左室收缩功能和缩小梗塞面积。
The left ventricular branches of rabbits were ligated for 45min and reperfused for 180min. The acute myocardial ischemia / reperfusion model was duplicated to observe the synergistic effect of isovolemic hemodilution and superoxide dismutase (SOD) on myocardial ischemia / reperfusion injury in rabbits And explore its possible mechanism. Forty animals were randomly divided into 4 groups: group Ⅰ (control group), group Ⅱ (dilution group), group Ⅲ (SOD group) and group Ⅳ (dilution + SOD group). Results: Compared with group Ⅰ, the systolic function (max systolic pressure, + dp / dtmax) of group Ⅱ and Ⅲ were significantly improved, and group Ⅳ and group Ⅲ were significantly improved compared with group Ⅰ. Compared with the infarction area of group Ⅰ (the percentage of left ventricular infarction area to the total left ventricular area was 18.1 ± 2.3%), infarct size in group Ⅱ, Ⅲ and Ⅳ was significantly reduced (11.4 ± 2.1% , 13.8 ± 2.2%, 8.3 ± 2.9% respectively). The infarction area in group Ⅳ was further reduced than that in group Ⅲ (P <0.05). Tip: Isotonic hemodilution and SOD on rabbit ischemia / reperfusion myocardial protective effect; the combination of the two can further improve left ventricular systolic function and reduce infarct size.