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目的探讨婴儿肝炎综合征（ＩＨＳ）时血清结合甘胆酸（ＳＣＧ）的变化及意义。方法用放射免疫法测定４２例ＩＨＳ患儿ＳＣＧ的含量。结果ＩＨＳ患儿各期ＳＣＧ含量均明显高于对照组（Ｐ＜０．０１），重症型与一般型相比差异也有显著性（Ｐ＜０．０１）。且ＳＣＧ含量的的变化较丙氨酸氨基转移酶（ＡＬＴ）异常出现早、恢复迟，并与血清总胆红素（ＳＴＢ）水平呈高度正相关（Ｐ＜０．０１）。结论ＳＣＧ含量的检测对ＩＨＳ的早期诊断及病情轻重与预后判断有一定的参考价值，重症型与一般型相比差异也有显著性（Ｐ＜０．０１）。且对肝细胞生理功能是否恢复正常的评估优于ＡＬＴ。
Objective To investigate the changes of serum bound glycocholic acid (SCG) in infantile hepatitis syndrome (IHS) and its significance. Methods The contents of SCG in 42 cases of IHS children were determined by radioimmunoassay. Results The levels of SCG in all stages of IHS were significantly higher than those in control group (P <0.01). There was also significant difference between severe type and normal type (P <0.01). The change of SCG content was earlier than that of alanine aminotransferase (ALT) and recovered later, and was positively correlated with serum total bilirubin (STB) level (P <0.01). Conclusion The detection of SCG has certain reference value for the early diagnosis of IHS and severity of illness and prognosis. The difference between severe type and normal type is also significant (P <0.01). And the assessment of whether the physiological function of hepatocytes returned to normal is superior to that of ALT.