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目的:颞下颌关节紊乱病是口腔科的一种常见病和多发病,精神心理因素是颞下颌关节紊乱病的一个主要病因。本文通过观察睡眠剥夺对大鼠行为学及咀嚼肌肌电图的影响,探讨睡眠剥夺在颞下颌关节紊乱病发病中的作用。方法:35只Wistar大鼠,随机分为5组:睡眠剥夺1d组、5d组、9d组、正常对照组和大平台对照组。采用改良多平台睡眠剥夺法(modified multiple plat-form method,MMPM)建立大鼠SD模型,观察大鼠行为学及咀嚼肌肌电图的变化。结果:睡眠剥夺1d组和5d组在旷场实验水平得分和垂直得分上均高于对照组,而睡眠剥夺9d组均低于对照组;睡眠剥夺1d、5d和9d组在松弛状态和紧咬状态时颞肌前后束及咬肌的电位均明显高于对照组,且两侧无明显差别,同时,睡眠剥夺组双侧颞肌和咬肌的肌电图静息期较对照组显著延长。结论:睡眠剥夺可使大鼠行为学发生改变并对咀嚼肌肌电图造成影响,这可能是颞下颌关节紊乱病的病因之一,为我们对颞下颌关节紊乱病的预防和治疗提供了一定的理论指导。
OBJECTIVE: Temporomandibular joint disorder is a common and frequently occurring disease in stomatology. Psychiatric factors are a major cause of temporomandibular disorder. In this paper, by observing the effects of sleep deprivation on the behavior of rats and the EMG of masticatory muscles, we explore the role of sleep deprivation in the pathogenesis of temporomandibular disorders. Methods: Thirty-five Wistar rats were randomly divided into 5 groups: sleep deprivation 1d group, 5d group, 9d group, normal control group and large platform control group. The SD model was established by modified multiple plat-form method (MMPM). The changes of behavior and the EMG of the masticatory muscles were observed. Results: Sleep deprivation 1d and 5d groups were significantly higher than the control group in the field open field and vertical scores, while sleep deprivation 9d group were lower than the control group; sleep deprivation 1d, 5d and 9d group in the relaxed state and tight bite State of the temporalis before and after the beam and masseter muscle potential were significantly higher than the control group, and there was no significant difference between the two sides, while sleep deprivation group bilateral temporal muscle and masseter electromyography resting period significantly longer than the control group. Conclusion: Sleep deprivation can change the behavior of rats and affect the electromyography of the masticatory muscles, which may be one of the causes of temporomandibular disorder, which provides a certain measure for the prevention and treatment of temporomandibular disorders Theoretical guidance.