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辅助放疗的目的在于期望其能够减少肿瘤的局部复发,而术前给予放疗还在于减少有活性的癌细胞血行播散的危险性。尽管传统观念认为播散发生于临床发现之前,术前放疗不能影响血行转移的发生,但从术前放疗应用之后对生存率的改善这一事实中,可以获得支持这一想法的证据。作者总结了很多单位进行的术前放疗的随机和非随机研究,以及术前术后联合放疗的结果。其中Sloan-Kettering 医院较早进行了小剂量术前放疗的研究。他们在术前10天内对病人盆腔照射10.0～20.0格雷,其结果与过去对照组5年生存率(45%)相比,获得了稍好的结果(55%)。该院在347例病人的随机对照研究之后,对小剂量术前放疗的效益处没能得出肯定的结论。Yale-New Haven 医院1963年开展了
The purpose of adjuvant radiotherapy is to expect that it can reduce the local recurrence of the tumor, and preoperative radiotherapy is also to reduce the risk of active cancer cells spreading blood. Although conventional wisdom holds that dissemination occurs before clinical detection, preoperative radiotherapy cannot affect the occurrence of hematogenous metastasis, but evidence of support for this idea can be obtained from the fact that preoperative radiotherapy has improved survival. The authors summarized randomized and non-randomized studies of preoperative radiotherapy performed by many units, as well as the results of preoperative and postoperative radiotherapy. Among them, Sloan-Kettering Hospital conducted an earlier study of low-dose preoperative radiotherapy. They irradiated the patient with pelvic radiation 10.0 to 20.0 Gray within 10 days before surgery, and the results were slightly better (55%) than the previous 5 year survival rate (45%) of the control group. After the randomized controlled study of 347 patients in this hospital, the benefit of low-dose preoperative radiotherapy failed to reach a firm conclusion. Yale-New Haven Hospital launched in 1963