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目的探讨吡蚜酮原药的急性、亚慢性及突变性毒性。方法按照GB15670-1995《农药登记毒理学试验方法》进行。结果①急性毒性属低毒;②致突变性的试验结果与对照组比较差异无统计学意义(P>0.05);③亚慢性毒性试验中:6 000 ppm浓度水平,雌鼠出现体重增长缓慢,心/体、肝/体、脾/体、肾/体和脑/体的比值增高,雄鼠出现血液红细胞计数减低,肝/体比值明显增高;1 500 ppm及以上浓度水平,雄鼠出现体重增长缓慢,脾重量减低,肾/体、脑/体比值明显增高。结论本试验提示吡蚜酮对动物的急性毒性低,无明显致突变作用。一定剂量的吡蚜酮可导致动物体重增长缓慢,肝/体、肾/体、脾/体比值增高,血液红细胞数目下降等。最大无作用剂量雌、雄分别为1 500 ppm(150.5 mg·kg-1bw-1·d-1)和375 ppm(29.6 mg·kg-1bw-1·d-1)。
Objective To investigate the acute, subchronic and mutagenic toxicity of pymetrozine. Methods in accordance with GB15670-1995 “pesticide registration toxicology test method”. Results ① The acute toxicity was low toxicity; ② The results of mutagenicity test showed no significant difference compared with the control group (P> 0.05); ③ In the sub-chronic toxicity test, the concentration of 6 000 ppm was slow, The ratio of heart / body, liver / body, spleen / body, kidney / body and brain / body increased, the blood red blood cell count decreased and the ratio of liver / body increased obviously in male rats; at the concentration of 1 500 ppm and above, Slow growth, reduced spleen weight, kidney / body, brain / body ratio was significantly higher. Conclusion This test suggests that pymetrozine has low acute toxicity to animals and no obvious mutagenic effect. A dose of pymetrozine can lead to slow body weight gain, increased liver / body, kidney / body, spleen / body ratio, decreased blood red blood cell count and the like. The maximum effective dose of 1 500 ppm (150.5 mg · kg-1 bw-1 · d-1) and 375 ppm (29.6 mg · kg-1 bw-1 · d-1) of male and female respectively.