以18β-甘草次酸和4-氨基苯酚为原料,在N,N′-二环己基碳二酰亚胺(DCC),1-羟基苯并三唑(HOBt)/4-N,N-甲基吡啶(DMAP),N-甲基吗啉(NMM)作用下合成了N-(4-羟基-苯基)-甘草次酸酰胺,通过DCC、DCC/HOBt催化有机酸形成酯、酰胺反应的历程解释了在DCC/HOBt催化体系中目标化合物产率高的原因,同时通过4-氨基苯酚在碱性环境中结构的变化及苯环上取代基的特性解释了标题化合物为主产物的原因。所合成的化合物通过IR,1H NMR,MS等方法进行了表征。 Using 18β-glycyrrhetinic acid and 4-aminophenol as raw materials in N, N’-dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBt) / 4-N, N- N- (4-hydroxy-phenyl) -glycylamidic acid amide was synthesized under the action of DMAP and NMM. DCC and DCC / HOBt catalyzed organic acids to form esters. The process explains the reason for the high yield of the target compound in the DCC / HOBt catalytic system. The reason why the title compound is the main product is explained by the structural changes of 4-aminophenol in alkaline environment and the substituents on the benzene ring. The synthesized compounds were characterized by IR, 1H NMR, MS and other methods.