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下尿路症状(LUTS)和勃起功能障碍(ED)均为老年男性的常见疾病,严重影响患者的生活质量。近年来许多流行病学调查对LUTS与ED的关联性进行研究分析,认为LUTS,尤其是其排尿症状、夜尿症状及个人困扰为ED的独立危险因素。LUTS与ED伴随发病可能主要涉及以下机制:①Rho-激酶表达/活性增强;②一氧化氮释放减少及内皮素-1的海绵体平滑肌收缩作用增强;③海绵体平滑肌肌球蛋白亚型组成改变;④自主神经兴奋性增强及海绵体平滑肌神经分布减少。LUTS与ED间关联性的研究为两者的临床诊疗提供了新的思路。现简要综述近年来LUTS与ED关系的研究进展。
Lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) are common diseases in older men and have a serious impact on the patient’s quality of life. In recent years, many epidemiological studies on the association between LUTS and ED research and analysis, that LUTS, especially urination symptoms, nocturnal symptoms and personal disturbance as independent risk factors for ED. The accompanying pathogenesis of LUTS and ED may mainly involve the following mechanisms: ①Rho-kinase expression / activity enhancement; ②Decrease of nitric oxide release and enhancement of contractile activity of endothelin-1 in the corpus cavernosum smooth muscle; ③Morphine subunit composition of cavernous smooth muscle changes; ④ autonomic excitability and sponge smooth muscle distribution decreased. The study of the relationship between LUTS and ED provides a new idea for clinical treatment of both. Now briefly summarize the research progress of the relationship between LUTS and ED in recent years.