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1896年McBride最早记载本病,尽管近年来医学进展很快,但本病的病因仍不清楚。病名也不统一,如恶性肉芽肿(英,法,瑞典),坏死性肉芽肿(德),致死性中线肉芽肿(美),进行性坏死性鼻炎(日)。本病预后极坏,死亡率高达80—90％。治疗方法:(1)放疗:1963年前多采用深部X线或镭,1964年后用钴~(60)或加速器照射;钴~(60)或加速器一次病灶量为200r,一周6次,3～4周内共照射3000—4000r。(2)手术:本文报告2例,1例作全鼻窦根治术,另一例作多窦开放加鼻中隔、中下甲摘除术。(3)抗癌剂:1963年以前使用马法兰(Marpharine)及氧化氮芥(Nitromine);1964年后全部动脉注射,
McBride first recorded the disease in 1896. Despite rapid medical advances in recent years, the cause of the disease remains unclear. The disease name is not uniform, such as malignant granuloma (British, French, Swedish), necrotic granulomatous (German), fatal midline granuloma (US), progressive necrotizing rhinitis (day). The prognosis of the disease is extremely bad and the mortality rate is as high as 80-90%. Treatment methods: (1) Radiotherapy: Many X-rays or radium were used before 1963. After 1964, they were irradiated with cobalt 60 or an accelerator. The amount of primary lesions of cobalt-(60) or accelerator was 200r, 6 times a week, 3 A total of 3000-4000r was irradiated in ~4 weeks. (2) Surgery: This article reports 2 cases, 1 case of radical sinus radical surgery, and another case of multi-sinus opening plus nasal septum, removal of middle and lower nails. (3) Anticancer agents: Marpharine and Nitromine were used before 1963; all arteries were injected after 1964,