论文部分内容阅读
目的 :探讨垂体腺瘤组织中垂体肿瘤转化基因 (PTTG)、内皮抑素 (endostatin)和碱性成纤维细胞生长因子 (bFGF)在侵袭性垂体腺瘤发生中的作用。方法 :应用逆转录聚合酶链式反应 (RT PCR)技术检测非侵袭性和侵袭性垂体腺瘤组织标本中PTTG ,endostatin和bFGFmRNA的表达水平。结果 :侵袭性腺瘤较非侵袭性腺瘤PTTG和bFGFmRNA表达明显增高 (均P <0 .0 1)。侵袭性腺瘤较非侵袭性腺瘤endostatinmRNA表达明显降低(P <0 .0 1)。结论 :垂体腺瘤侵袭性的发生可能与PTTG和bFGF表达增高及endostatin表达下调有关 ,其作用机制可能与PTTG高表达后改变了肿瘤血管的生成与抑制之间的平衡有关
Objective: To investigate the role of pituitary tumor transforming gene (PTTG), endostatin and bFGF in the development of invasive pituitary adenomas. Methods: The expressions of PTTG, endostatin and bFGF mRNA in non-invasive and invasive pituitary adenomas specimens were detected by reverse transcription-polymerase chain reaction (RT-PCR). Results: The expressions of PTTG and bFGF mRNA in invasive adenomas were significantly higher than those in non-invasive adenomas (all P <0.01). The expression of endostatin mRNA in invasive adenomas was significantly lower than that in non-invasive adenomas (P <0.01). Conclusions: The invasiveness of pituitary adenomas may be related to the increased expressions of PTTG and bFGF and the down-regulation of endostatin. The mechanism may be related to the balance between the generation and suppression of tumor angiogenesis after the high expression of PTTG