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目的探讨盐酸右美托咪定对小儿手术应激反应的作用。方法 80例小儿扁桃体、腺样体切除术患儿,使用信封抽取法分成观察组和对照组,各40例。两组均进行常规麻醉,对照组在常规麻醉基础上加用生理盐水,观察组在常规麻醉基础上采用盐酸右美托咪定。比较两组临床疗效。结果对照组麻醉后20 min的血糖、皮质醇和肾上腺素浓度均高于观察组(P<0.05);观察组的术后苏醒时间和拔管时间低于对照组(P<0.05)。结论盐酸右美托咪定可以有效减少小儿手术患儿的术中应激反应,值得在临床实践中应用。
Objective To investigate the effect of dexmedetomidine hydrochloride on stress response in children. Methods Eighty children with pediatric tonsillectomy and adenoidectomy were divided into observation group and control group by envelope extraction method, 40 cases each. Both groups were given routine anesthesia. The control group was given normal saline on the basis of routine anesthesia. The observation group was treated with dexmedetomidine hydrochloride on the basis of routine anesthesia. The clinical efficacy of the two groups were compared. Results The levels of blood glucose, cortisol and epinephrine in the control group were significantly higher than those in the observation group 20 min after anesthesia (P <0.05). The recovery time and extubation time in the observation group were lower than those in the control group (P <0.05). Conclusion Dexmedetomidine hydrochloride can effectively reduce the intraoperative stress response in children with pediatric surgery, and is worthy of application in clinical practice.