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目的了解供精人工授精子代出生缺陷发生情况,评价应用冷冻精液实施供精人工授精出生子代的安全性。方法对2007年4月至2012年9月在我院行供精人工授精分娩的围生儿进行监测。结果 2007年4月至2012年9月共监测12609周期,出生1745个子代,其中发生出生缺陷17例,出生缺陷发生率为0.97‰。出生缺陷分类以先天性心脏病发生率最高,其次为唇腭裂,其他为双手多指畸形、先天性肛门闭锁、先天性胆道闭锁、先天性脑积水、婴儿局限性线状鱼鳞病、先天性白内障等。供精人工授精子代出生缺陷发生率低于卫生部发布一般人群发生率。结论冷冻精液行供精人工授精的新生儿出生缺陷发生率低于一般人群发生率,冷冻精液行供精人工授精技术是安全的。
Objective To understand the incidence of artificial insemination on behalf of birth defects, evaluation of the application of frozen semen for artificial insemination of the safety of offspring. Methods From April 2007 to September 2012, our hospital monitored the perinatal delivery of artificial insemination and delivery. Results From April 2007 to September 2012, 12609 cycles were monitored and 1745 offspring were born. There were 17 birth defects and the incidence of birth defects was 0.97 ‰. Classification of birth defects in congenital heart disease the highest incidence, followed by cleft lip and palate, the other for the hands and more finger deformities, congenital anatomy, congenital biliary atresia, congenital hydrocephalus, baby limited linear ichthyosis, congenital Cataract and so on. For artificial insemina on behalf of the birth defect rate is lower than the Ministry of Health released the general population incidence. Conclusion The incidence of birth defects in frozen semen with artificial insemination is lower than that in the general population. It is safe to use frozen semen to provide artificial insemination technique.