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目的探讨冠状动脉粥样硬化性心脏病患者(CAD)行冠状动脉支架置入术(CS)前后,血浆中髓过氧化酶(MPO)的变化。方法78例行CS术患者,分为急性冠脉综合征(ACS,51例)组和稳定型心绞痛(SAP,27例)组。分别在CS手术前后取血测MPO、C反应蛋白(CRP),观察两指标者在手术前后的变化及关系。结果术前ACS组血浆MPO、CRP均明显高于SAP组,手术后两组CRP升高明显,而MPO的差别则不显著;术前ACS组MPO水平与CRP显著相关(r=0.341,P<0.05)。结论血浆MPO与冠脉斑块急性损伤、炎症的相关性小,可作为预测、评估ACS的有效指标。
Objective To investigate the changes of plasma myeloperoxidase (MPO) before and after coronary stenting (CS) in patients with coronary atherosclerotic heart disease (CAD). Methods A total of 78 patients undergoing CS surgery were divided into acute coronary syndrome (ACS, 51 cases) and stable angina (SAP, 27 cases). Blood samples were collected before and after CS surgery to measure MPO and C-reactive protein (CRP), and to observe the changes and relationships between the two indexes before and after surgery. Results The plasma levels of MPO and CRP in preoperative ACS group were significantly higher than those in SAP group. The postoperative CRP levels were significantly increased in both groups, but not in MPO group. The level of MPO in preoperative ACS group was significantly correlated with CRP (r = 0.341, P < 0.05). Conclusion The correlation between plasma MPO and acute lesion of coronary artery plaque and inflammation is small, which can be used as an effective index to predict and evaluate ACS.