论文部分内容阅读
目的:观察止痛化癥胶囊联合孕三烯酮胶囊治疗子宫腺肌病的临床疗效,及对患者血液高凝状态的改善情况。方法:按照随机数字表法将86例子宫腺肌病患者分为观察组和对照组各43例。2组均给予孕三烯酮胶囊治疗,观察组另给予止痛化癥胶囊治疗。观察2组治疗前后的凝血指标[活化部分凝血活酶时间(APTT)、血浆凝血酶时间(TT)、血浆纤维蛋白原(Fi B)]、子宫体积及痛经评分的变化,比较2组临床疗效,随访1年后统计复发率。结果:治疗后,2组APTT、TT均较治疗前缩短(P<0.05),Fi B水平均较治疗前降低(P<0.05);观察组APTT、TT均短于对照组(P<0.05),Fi B水平低于对照组(P<0.05)。治疗后,2组子宫体积均较治疗前减小(P<0.05),痛经评分均较治疗前降低(P<0.05);观察组的子宫体积小于对照组(P<0.05),痛经评分低于对照组(P<0.05)。观察组总有效率88.37%,高于对照组的69.77%(P<0.05)。随访1年,观察组复发率7.89%,对照组复发率33.33%,2组比较,差异有统计学意义(P<0.05)。结论:止痛化癥胶囊联合孕三烯酮胶囊治疗子宫腺肌病,能有效改善血液高凝状态,减小子宫体积,减轻痛经状况,继而达到提高临床疗效和降低复发率的目的。
Objective: To observe the clinical curative effect of analgesic capsule combined with gestrinone capsule in the treatment of adenomyosis and to improve the state of blood hypercoagulability in patients. Methods: According to the random number table, 86 cases of adenomyosis were divided into observation group and control group, 43 cases each. Two groups were given gestrinone capsule treatment, the observation group were given another analgesic capsule treatment. The changes of coagulation index (APTT, TT, Fi B), uterine volume and dysmenorrhea score were observed before and after treatment in two groups, and the clinical efficacy was compared between the two groups , Followed up for 1 year after the statistical rate of recurrence. Results: After treatment, the APTT and TT in both groups were shorter than those before treatment (P <0.05) and Fi B levels were lower than those before treatment (P <0.05). APTT and TT in the observation group were shorter than those in the control group (P <0.05) , Fi B level was lower than the control group (P <0.05). After treatment, the volume of uterus in both groups decreased (P <0.05) and the score of dysmenorrhea was lower than that before treatment (P <0.05). The uterus volume in observation group was smaller than that in control group (P <0.05) Control group (P <0.05). The total effective rate was 88.37% in the observation group, which was higher than that in the control group (69.77%, P <0.05). The follow-up of 1 year showed that the recurrence rate was 7.89% in the observation group and 33.33% in the control group. There was significant difference between the two groups (P <0.05). Conclusion: The analgesic capsule combined with gestrinone capsule in the treatment of adenomyosis can effectively improve the blood hypercoagulability, reduce the uterine volume, reduce the dysmenorrhea, and then achieve the purpose of improving clinical efficacy and reducing the recurrence rate.