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本文研究了竹红菌甲素和还原型谷胱甘肽(GluSH)间的光诱导氧化还原作用。甲素是3,10-二羟基-4,10-苝醌衍生物。在GluSH作为电子给体时,甲素经受可见光诱导的单电子还原,生成年醌自由基或二氢甲素,取决于pH值,同时GluSH被氧化。甲素的单电子还原量子效率随pH值增加而增加。在充氧溶液中甲素敏化氧化GluSH的反应通过类型Ⅰ和Ⅱ的混合机制进行。用ESR检测到了通过Fenton反应产生的羟基自由基。在脂质体包裹的甲素溶液中用动力学测定方法证明了甲素敏化GluSH的氧化是通过类型Ⅱ机制进行的。
In this paper, the light-induced redox interaction between hypocrellin A and glutathione (GluSH) was studied. A is a 3,10-dihydroxy-4,10-perylenequinone derivative. When GluSH is used as an electron donor, alanine undergoes visible light-induced single electron reduction to generate quinone or hydantoin, depending on the pH and GluSH is oxidized. The single electron reduction quantum efficiency of A increases with the increase of pH. The reaction of a-sensitized and oxidized GluSH in an oxygenated solution is carried out by a mixing mechanism of type I and II. Hydroxyl radicals generated by the Fenton reaction were detected by ESR. In the liposome-encapsulated A-solution, kinetics was used to demonstrate that the oxidation of a-sensitized GluSH was carried out by a type II mechanism.