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缺氧诱导因子1(hypoxia-inducible factor-1,HIF-1)是1992年Semenza等在Hep3B细胞中发现的,并于1995年克隆成功。HIF-1α为其调节亚基和活性亚基,是近年来肿瘤研究的热点之一,但国内外对其在胃癌中的研究尚不多见。1 HIF-1αHIF-1是由碱性螺旋-环-螺旋(bHLH)-PAS的120KDα亚基
Hypoxia-inducible factor-1 (HIF-1) was discovered by Semenza et al in Hep3B cells in 1992 and cloned in 1995. HIF-1α regulates subunits and active subunits, which is one of the hot spots in cancer research in recent years. However, its research in gastric cancer is rare at home and abroad. 1 HIF-1α HIF-1 is composed of 120KDα alpha subunit of basic helix-loop-helix (bHLH) -PAS