论文部分内容阅读
目的评价儿泻停联合蜡样芽胞杆菌活菌治疗小儿轮状病毒性肠炎的疗效及安全性。方法将2016年8月—2016年12月我院门诊及病房确诊为轮状病毒性肠炎的210例患儿,随机分为治疗组105例和对照组105例,2组患儿在蜡样芽胞杆菌活菌口服及对症支持处理的基础上分别予儿泻停、蒙脱石散治疗,比较2组治疗第72 h后疗效及药物不良反应。结果治疗组在经治疗72 h后腹泻患儿在发热、呕吐、腹胀、脱水纠正及改善精神倦怠、食欲等临床症状恢复明显优于对照组,差异有统计学意义(P<0.05),治疗组总有效率(95.2%)显著高于对照组(69.5%),差异有统计学意义(χ2=23.916,P<0.01);同时治疗组在治疗72小时后腹泻次数及大便性状恢复的时间明显少于对照组,差异有统计学意义(P<0.05)。治疗组便秘的发生率(5.7%)少于对照组(11.3%),差异有统计学意义(χ2=4.1102,P<0.05)。结论儿泻停联合蜡样芽胞杆菌活菌治疗小儿轮状病毒性肠炎安全、疗效显著,值得临床推广应用。
Objective To evaluate the curative effect and safety of combined treatment of pediatric and children with rotavirus enteritidis via bacillus cereus. Methods A total of 210 children diagnosed as rotavirus enteritis from our hospital from August 2016 to December 2016 were randomly divided into treatment group (105 cases) and control group (105 cases) Bacilli viable oral and symptomatic treatment based on the treatment were given to children stop diarrhea, montmorillonite treatment, the treatment of 72 hours after the two groups compared the efficacy and adverse drug reactions. Results In 72 hours after treatment, the clinical symptoms of children with diarrhea were better than control group in the recovery of fever, vomiting, abdominal distension, dehydration and improvement of mental fatigue, appetite, the difference was statistically significant (P <0.05) The total effective rate (95.2%) was significantly higher than that of the control group (69.5%), the difference was statistically significant (χ2 = 23.916, P <0.01). At 72 hours after treatment, the time of diarrhea and stool recovery were significantly less In the control group, the difference was statistically significant (P <0.05). The incidence of constipation in the treatment group (5.7%) was less than that in the control group (11.3%), the difference was statistically significant (χ2 = 4.1102, P <0.05). Conclusions Pediatric diarrhea combined with viable Bacillus cereus can treat children with rotavirus enteritis safely and has a significant curative effect. It is worthy of clinical application.