为探讨丁胺卡那霉素新的给药方法，提高其临床疗效及安全性，采用丁胺卡那霉素大剂量每日每公斤体重１０ｍｇ给药的方法，治疗１５例无肾功能不全的呼吸系统感染患者，并于疗程（共８天）前后检测其人体药代动力学及肾功能指标。结果表明：受试患者对此给药方法耐受良好，疗效满意，未出现明显的药物性肾功能损害及其它药物毒性反应，特别是在给药后血药浓度峰值达到或超过通常认为是中毒水平的情况下，各药代动力学指标于疗程始末比较未见显著变化，达到了在提高靶器官药物浓度的同时避免体内药物蓄积的治疗目的 In order to explore the new administration method of amikacin and to improve its clinical curative effect and safety, amoxicillin was used to treat 10 cases of renal insufficiency Respiratory infections, and in the course of treatment (a total of 8 days before and after testing its human pharmacokinetics and renal function parameters. The results showed that: the test patients were well tolerated, satisfactory curative effect, no obvious drug-induced renal dysfunction and other drug toxicity, especially after administration peak plasma concentration reached or exceeded the usually considered toxic Level, the pharmacokinetic parameters in the course of the beginning and the end of the treatment showed no significant change, reaching the goal of improving the concentration of target organ drugs, while avoiding the purpose of the treatment of the body of drug accumulation