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目的 研究儿童癫痫服用丙戊酸后血药浓度与给药剂量的关系.方法 对48例癫痫失神性发作儿童患者服用丙戊酸,用荧光偏振免疫法(FPIA)监测血药浓度.结果 达稳态后给药剂量与血药浓度的变化有着密切的关系.结论 监测血药浓度,及时调整给药剂量,对控制儿童患者癫痫失神发作至关重要.
Objective To study the relationship between plasma concentration and dose of epirubicin after taking epirubic acid in children.Methods 48 cases of children with epileptic dementia were treated with valproic acid and the plasma concentration was monitored by fluorescence polarization immunoassay There was a close relationship between dose and the change of plasma concentration.Conclusion It is very important to monitor the blood concentration and adjust the dosage in time to control the seizure absence in children.