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目的 比较糖尿病肾病 (DN)患者治疗前后血管内皮生长因子 (VEGF)、血管紧张素Ⅱ (ATⅡ )等含量的变化。方法 用放射免疫法测定正常对照组及糖尿病 (DM )和DN患者血浆VEGF、ATⅡ的含量。结果 DN组和DM组血浆VEGF和ATⅡ浓度明显高于对照组 (P <0 0 1) ;治疗后VEGF、ATⅡ含量明显低于治疗前。结论 VEGF在糖尿病肾病的形成和发展过程中可能起重要作用
Objective To compare the changes of vascular endothelial growth factor (VEGF) and angiotensin Ⅱ (AT Ⅱ) in patients with diabetic nephropathy (DN) before and after treatment. Methods Radioimmunoassay was used to determine the levels of plasma VEGF and ATⅡ in normal control group, diabetic (DM) and DN patients. Results The plasma levels of VEGF and ATⅡ in DN group and DM group were significantly higher than those in control group (P <0.01). The contents of VEGF and ATⅡ in DN group and DM group were significantly lower than those before treatment. Conclusion VEGF may play an important role in the formation and development of diabetic nephropathy