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目的：观察家兔肾缺血1小时再灌流2小时和24小时的组织学变化。方法：31只日本大耳白兔随机分为4组，左肾缺血1小时再灌流2小时组和再灌流24小时组及各自的对照组，采用肾动脉夹闭法制成急性缺血再灌流损伤模型。结果：再灌流2小时组和再灌流24小时组的左肾系数、肾组织中的白细胞滞流数、肾小管计分或肾小管坏死数，同各自的对照组比较，差异均具显著性（P＜0．05）；再灌流2小时和24小时组的肾小球滤过膜、肾近端小管等均呈变性或坏死性改变；后者的改变以24小时组更为严重。结论：近端小管比肾小球滤过膜对缺血再灌流刺激更为敏感，白细胞可能参与了缺血再灌流肾损伤。
OBJECTIVE: To observe the histological changes of renal ischemia 1 hour and 2 hours and 24 hours after reperfusion in rabbits. Methods: Thirty-one Japanese white rabbits were randomly divided into 4 groups: 1-hour ischemia-reperfusion group, 2-hour ischemia group and 24-hour reperfusion group and their respective control groups. Renal artery occlusion Damage model. RESULTS: The left renal coefficient, the number of leukocytes in renal tissue, the number of renal tubules and the number of renal tubular necrosis in 2-hour reperfusion group and 24-hour reperfusion group were significantly different from those in control group P <0.05). The glomerular filtration membrane and renal proximal tubule in 2 hours and 24 hours after reperfusion showed degenerative or necrotic changes. The latter changed more severely in 24 hours group. CONCLUSION: The proximal tubules are more sensitive to the stimulation of ischemia-reperfusion than the glomerular filtration membrane. Leukocytes may be involved in the renal injury induced by ischemia-reperfusion.