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肥胖一般与血清中胰岛素样生长因子-1(insulin-like growth factor 1,IGF-1)水平降低、氧化应激、线粒体损伤及心肌功能障碍有关。本研究旨在阐明IGF-1对高脂饮食引起的氧化、心肌形态及线粒体损伤的作用。分别以低脂和高脂饮食喂养FVB和心肌特异性IGF-1过表达转基因小鼠。高脂饮食饲养导致糖耐量异常,血清瘦素、白介素-6、胰岛素和甘油三酯的水平升高,IGF-1水平降低。心脏超声结果提示:高脂饮食饲养
Obesity is generally associated with reduced serum insulin-like growth factor-1 (IGF-1) levels, oxidative stress, mitochondrial damage, and myocardial dysfunction. The purpose of this study was to elucidate the effects of IGF-1 on oxidative, myocardial morphological and mitochondrial damage induced by a high-fat diet. FVB and cardiac-specific IGF-1 overexpressing transgenic mice were fed on a low-fat and high-fat diet, respectively. High-fat diets resulted in impaired glucose tolerance, increased levels of serum leptin, interleukin-6, insulin and triglycerides, and decreased IGF-1 levels. Echocardiography prompted: high-fat diet