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目的了解山丘型血吸虫病轻疫区人群血吸虫病抗体水平的变化规律,为评价免疫诊断方法提供参考。方法选择四川省蒲江县古佛村,每年秋季用间接血凝试验(IHA)检查村民,血阳者再作Kato-Katz法检查。筛选出2006-2013年连续参加检查的人群,检查分析人群血吸虫抗体阳性率、抗体滴度、每克粪便虫卵数(EPG)等的变化情况。结果 2006-2013年有263人连续参加了血吸虫病检查,人群抗体阳性率从4.19%下降到1.83%,人群抗体滴度(GMRT)从1.29下降到1.07。抗体阳性者转归以阴转为主,滴度逐年降低;阴性者维持阴性为主。总血清阳性率与总感染率呈正相关(r=0.33,P<0.05)。结论四川省蒲江县古佛村山丘型血吸虫病轻疫区人群血吸虫抗体阳性率维持在较高水平,应开发适用于不同流行程度疫区的血吸虫病免疫诊断试剂。
Objective To understand the variation of schistosomiasis antibody level in schistosomiasis endemic areas of schistosomiasis, and to provide a reference for the evaluation of immunological methods. Methods The ancient Buddha village in Pujiang County of Sichuan Province was selected. Every autumn, the villagers were inspected by the indirect hemagglutination test (IHA). The Kato-Katz method was used to check the blood of the villagers. We screened out the consecutive groups of people who participated in the examination from 2006 to 2013, and examined and analyzed the changes of the positive rate of schistosoma japonicum antibody, the antibody titer, the number of egg per gram of stool egg (EPG) and so on. Results From 2006 to 2013, 263 people participated in the schistosomiasis test continuously. The positive rate of the antibody in the population dropped from 4.19% to 1.83% and the antibody titer (GMRT) of the population dropped from 1.29 to 1.07. The results of antibody positive were mainly negative conversion, and the titer decreased year by year. The negative ones were mainly negative. The positive rate of total serum was positively correlated with the total infection rate (r = 0.33, P <0.05). Conclusion The prevalence of schistosoma japonicum antibodies in schistosomiasis endemic areas in Gufo village, Pujiang County, Sichuan Province is still high. Immunological diagnostic reagents for schistosomiasis should be developed for epidemic areas with different epidemic proportions.