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目的：探讨青白栓对实验性溃疡性结肠炎的药效学作用。方法：对小鼠进行醋酸腹腔注射,番泻叶水煎液灌胃后,应用青白栓进行治疗,以观察其药效学作用。结果：青白栓高、中剂量组对醋酸引起的小鼠毛细血管通透性均有明显抑制作用,对醋酸引起的小鼠扭体痛均有镇痛作用,对番泻叶引起的腹泻均有不同程度的止泄作用,与组相比有统计学意义(P＜0．05,P＜0．01)。结论：青白栓具有明显的抗炎,镇痛、止泻作用。
Objective: To investigate the pharmacodynamic effects of Qingbai Suppository on experimental ulcerative colitis. METHODS: Mice were treated with intraperitoneal injection of acetic acid and senna saccharin decoction was intragastrically administered. Qingbai suppository was used for treatment to observe its pharmacodynamic effects. RESULTS: The high and middle doses of Qingbai Suppository significantly inhibited capillary permeability of mice induced by acetic acid, and had analgesic effect on acetic acid-induced writhing in mice. Both had diarrhea caused by senna. The effect of different degrees of stoppage was statistically significant compared with the group (P<0.05, P<0.01). Conclusion: Qingbai suppository has obvious anti-inflammatory, analgesic and antidiarrheal effects.