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目的探讨血尿酸浓度升高是否为冠心病的独立预测因子。方法对上海交通大学附属第六人民医院心内科2003-09~2004-03住院患者临床资料进行回顾性分析,选择经冠状动脉造影证实的连续性冠心病患者118例(稳定型心绞痛36例,不稳定型心绞痛28例,急性心肌梗死54例),年龄66(65·79±10·03)岁,其中男94例、女24例;同期冠脉造影正常的连续性入院患者67例作为对照组,年龄61(60·75±11·98)岁,其中男43例、女24例。入院第2天清晨取空腹12h抽取静脉血进行血尿酸、血脂等各种生化检查,详细询问包括吸烟、高血压等病史。入院期间行冠脉造影检查。结果冠心病组血尿酸浓度高于对照组[(372·31±100·28)mmol/L对(340·08±81·58)mmol/L,P=0·028],冠心病组之间血尿酸浓度差异并无显著性。但Logistic回归分析显示血尿酸并非冠心病的独立危险因素。结论血尿酸浓度升高可能只是动脉粥样硬化的一个标志,而非冠心病的独立危险因素。
Objective To investigate whether elevated serum uric acid concentration is an independent predictor of coronary heart disease. Methods The clinical data of inpatients from September 2003 to March 2004 in Department of Cardiology of the Sixth People’s Hospital Affiliated to Shanghai Jiaotong University were retrospectively analyzed. 118 consecutive patients with coronary heart disease confirmed by coronary angiography (36 patients with stable angina, 28 patients with stable angina and 54 patients with acute myocardial infarction), aged 66 (65 · 79 ± 10 · 03) years old, including 94 males and 24 females; 67 consecutive patients with normal coronary angiography during the same period served as control group , Age 61 (60 75 ± 11 · 98) years old, including 43 males and 24 females. The first day of admission on the second day of fasting 12h blood samples taken venous blood uric acid, blood lipids and other biochemical tests, asked in detail, including smoking, hypertension and other medical history. Coronary angiography during admission. Results The concentration of serum uric acid in coronary heart disease group was significantly higher than that in control group [(372.31 ± 100.28) mmol / L vs (340.08 ± 81.58) mmol / L, P = 0.028] Serum uric acid concentration difference was not significant. However, Logistic regression analysis showed that serum uric acid was not an independent risk factor for coronary heart disease. Conclusion The elevated serum uric acid concentration may be only a marker of atherosclerosis, not an independent risk factor for coronary heart disease.