目的　探讨家兔多次使用后是否对细菌内毒素致热产生耐受现象。方法　对家兔进行常规热原试验 ,间隔两天做一次 ,共做三次。每次对同一家兔注射同一剂量的内毒素 ,间隔 15min记录一次温度。结果　第三次家兔升温幅度明显低于第一次和第二次的结果。结论　家兔多次使用后对细菌内毒素致热原产生耐受性 Objective To investigate whether repeated exposure of bacteria to bacterial endotoxemia caused by heat tolerance. Methods Rabbits routine pyrogen test, done once every two days, a total of three times. Each time the same rabbit is injected with the same dose of endotoxin, the temperature is recorded once every 15 minutes. Results The temperature of the third rabbits was obviously lower than the first and second results. Conclusions After repeated use in rabbits, endotoxin-induced pyrogen causes bacteria to be tolerated