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目的 了解双生子A型人格与高血压及血液生化指标的关系。方法 利用遗传流行病学方法对青岛市89对 2 4岁以上双生子 (同卵 55对 ,异卵 34对 )进行调查。并进行A型人格测试 ,以比较同卵与异卵双生子A型人格得分的相关程度、A型人格及血压的一致性。推测遗传与环境因素对A型人格的影响 ,,A型人格与高血压的关系 ,并探讨血液生化指标与A型人格的关系。结果 经KAPPA一致性检验 ,同卵 (MZ)双生子之间A型人格存在着显著的一致性 (P <0 0 0 1 ) ,而异卵 (DZ)双生子之间的一致性无显著性差异 (P =0 80 2 )。同时 ,MZ双生子之间A型人格和血压也存在显著的一致性 (P <0 0 0 1 ) ,而DZ双生子之间A型人格和血压无明显一致性 (P =0 1 0 2 )。有A型人格的双生子血压的收缩压明显高于非A型人格的双生子 (P <0 0 5)。许多生化指标与A型人格因素相关 ,但是所计算出的相关系数大都小于 0 30 ,属于弱相关。结论 MZ双生子A型人格及高血压之间存在着显著的一致性 ,而这种一致性在DZ双生子表现不明显。A型人格是高血压的危险因素之一。A型人格与所研究血液基本生化指标之间相关较弱
Objective To understand the relationship between twins type A personality and hypertension and blood biochemical parameters. Methods A total of 89 pairs of twins (55 pairs of identical eggs and 34 pairs of different eggs) were investigated in Qingdao City using genetic epidemiology. And a type A personality test to compare the same egg and fraternal twins type A personality scores related to type A personality and blood pressure consistency. We speculate on the influence of genetic and environmental factors on type A personality, the relationship between type A personality and hypertension, and explore the relationship between blood biochemical markers and type A personality. Results The results of KAPPA test showed that there was significant consistency between type A personality in identical (MZ) twins (P <0.01 01), while there was no significant difference in twin between DZ twins Differences (P = 0 80 2). At the same time, there was also a significant agreement between type A personality and blood pressure between MZ twins (P <0.01), while there was no significant consistency between type A personality and blood pressure between two twin births (P = 0 102) . Systolic blood pressure of twins with type A personality was significantly higher than those of non-type A personality (P <0.05). Many biochemical indicators are related to type A personality factors, but most of the calculated correlation coefficients are less than 0 30 and are weakly related. Conclusion There is a significant agreement between MZ twins type A personality and hypertension, and this consistency is not obvious in DZ twins. Type A personality is one of the risk factors for hypertension. There is a weak correlation between type A personality and the basic biochemical markers of blood studied