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目的 探讨肠内营养对脑梗死致急性假性球麻痹 (APBP)及其并发症的疗效。方法 将 6 0例脑梗死致 APBP患者随机分成营养组和对照组 ,观察二组患者治疗后吞咽困难改善率、肺部感染发生率、神经功能改善率和 T淋巴亚群的变化。结果 经 10天治疗后 ,营养组和对照组吞咽困难改善率、肺部感染发生率、神经功能改善率分别为 83.3%和 5 6 .7% (P <0 .0 5 ) ;13.3%和 40 % (P <0 .0 5 ) ;76 .7%和 46 .7% (P<0 .0 5 )。另外 ,肠内营养组治疗后抑制性免疫指标 CD8较治疗前和对照组治疗后明显下降 (P<0 .0 5 ) ,而增强性免疫指标 CD3、CD4和 CD4/CD8较治疗前和对照组治疗后显著提高 (P<0 .0 5 )。结论 肠内营养能提供肌体所需要的蛋白、碳水化合物和脂肪等成分。对 APBP患者存在的吞咽困难、营养不良不仅能提高人体细胞免疫功能 ,而且能减少并发症、提高疗效、从而改善预后。
Objective To investigate the effect of enteral nutrition on acute pseudobulbar palsy (APBP) and its complications caused by cerebral infarction. Methods Sixty cases of APBP induced by cerebral infarction were randomly divided into nutritional group and control group. The improvement rate of dysphagia, the incidence of pulmonary infection, the rate of improvement of neurological function and the changes of T lymphocyte subsets in the two groups were observed. Results After 10 days of treatment, the improvement rate of dysphagia, the incidence of pulmonary infection and the improvement of neurological function of the nutrition group and the control group were 83.3% and 56.7% (P <0. 05), 13.3% and 40 % (P <0.05); 76.7% and 46.7% (P <0.05). In addition, CD8, an immunosuppressive index after enteral nutrition treatment, was significantly lower than that before treatment and the control group (P <0.05), while the enhanced immune markers CD3, CD4 and CD4 / CD8 were significantly lower than those before treatment and the control group After treatment significantly increased (P <0. 05). Conclusion Enteral nutrition can provide the body needs protein, carbohydrate and fat and other ingredients. In patients with APBP dysphagia, malnutrition can not only improve human cellular immune function, but also reduce complications and improve efficacy, thereby improving the prognosis.