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为探索巨噬细胞集落刺激因子、清道夫受体、氧化型低密度脂蛋白与动脉粥样硬化的关系，观察了重组人巨噬细胞集落刺激因子对小鼠腹腔巨噬细胞清道夫受体途径的影响以及重组人巨噬细胞集落刺激因子对氧化型低密度脂蛋白所致细胞内胆固醇酯积聚的影响．结果发现重组人巨噬细胞集落刺激因子能增加培养的小鼠腹腔巨噬细胞表面的清道夫受体数目，使之对氧化型低密度脂蛋白的结合和降解呈现剂量和时间依赖性增加，并使细胞内胆固醇酯积聚增多．表明巨噬细胞集落刺激因子可通过增加清道夫受体数目使小鼠腹腔巨噬细胞对氧化型低密度脂蛋白的结合和降解增多，从而增加细胞内胆固醇酯含量，促进动脉壁内泡沫细胞形成．
In order to explore the relationship between macrophage colony-stimulating factor, scavenger receptor and oxidized low density lipoprotein and atherosclerosis, we observed the effect of recombinant human macrophage colony-stimulating factor on scavenger receptor pathway of murine peritoneal macrophages And the effects of recombinant human macrophage colony-stimulating factor on the accumulation of intracellular cholesterol esters induced by oxidized low density lipoprotein (LDL). The results showed that recombinant human macrophage colony-stimulating factor increased the number of scavenger receptors on the surface of cultured mouse peritoneal macrophages in a dose and time-dependent manner for the binding and degradation of oxidized low-density lipoprotein Increased intracellular cholesterol ester accumulation. It is indicated that macrophage colony stimulating factor can increase the binding and degradation of oxidized low density lipoprotein in mouse peritoneal macrophages by increasing the number of scavenger receptors, thereby increasing the intracellular cholesterol ester content and promoting the formation of foam cells in the arterial wall .