目的通过对细胞色素P450酶的了解,尤其是它的多态性在药物不良反应中的作用及与药物的相互作用、对药物代谢的影响,为指导临床合理用药、避免药物不良反应、实施个体化用药提供参考。方法 Taqman探针技术测定P450酶单核苷酸的多态性。结果与结论 P450酶基因多态性造成个体用药差异,根据患者P450酶的基因型可以了解个体某类药物的代谢情况,从而利于临床医生合理选择适宜的药物和剂量,或联合用药时进行合理配伍。 Objective To understand the effects of cytochrome P450 enzyme, especially its polymorphism in adverse drug reaction, its interaction with drugs and its influence on drug metabolism, to guide clinical rational use of drugs and to avoid adverse drug reactions, Use of drugs for reference. Methods Taqman probe was used to determine the single nucleotide polymorphism of P450 enzyme. RESULTS AND CONCLUSION: The polymorphism of P450 enzyme caused individual differences in drug use. According to the genotype of P450 enzyme, the metabolism status of certain drugs can be understood, which is beneficial to the clinicians to choose appropriate drugs and dosage rationally or rationally when combined with drugs .