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目的探讨胃癌术前血液流变与甲襞微循环的改变，为临床提供其防治参考依据。方法２２例胃癌确诊的患者为观察组，２７例健康人为对照组。采用ＸＧ—８微循环检测仪和Ｒ２０全自动血流变检测仪，进行微循环、血流变检测。结果胃癌术前，血流变高、中、低切变率值，明显高于对照组（Ｐ＜０．０１）。微循环检测按照田牛加权积分值，总积分无明显差别（Ｐ＞０．０５）。结论胃癌术前血流变明显增高，可能由于：（１）组织相对缺氧使血小板聚集、血浆中各种蛋白异常致病人全血粘度增高。（２）肿瘤的生长，产生一种蛋白酸，能激活凝血因子而导致凝血。（３）肿瘤组织释放肿瘤标志蛋白，如癌胚抗原，引起血粘度增高、（４）肿瘤细胞随血流转移可使血粘度增高。
Objective To investigate the changes of preoperative hemorheology and nailfold microcirculation in gastric cancer, and provide reference for clinical prevention and treatment. Methods Twenty-two cases diagnosed with gastric cancer were observed group, and 27 healthy people were control group. XG-8 microcirculation detector and R20 automatic blood rheology detector were used to detect microcirculation and blood rheology. Results Before operation, the values of high, medium and low shear rate of gastric blood flow were significantly higher than those of the control group (P<0.01). The microcirculation test was performed according to the weighted integral value of the cattle, and there was no significant difference in the total scores (P>0.05). Conclusions Preoperative blood flow changes of gastric cancer are significantly higher, which may be due to: (1) tissue hypoxia causes platelet aggregation and various protein abnormalities in the plasma cause increased blood viscosity. (2) The growth of the tumor produces a protein acid that activates coagulation factors and causes coagulation. (3) tumor tissue release of tumor marker proteins, such as carcinoembryonic antigen, cause increased blood viscosity, (4) tumor cells with blood flow can increase blood viscosity.