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在20%FeCl3造成大鼠颈总动脉血栓形成的模型上,分别预防(血栓形成前)和治疗(血栓形成后)应用合成的纤维蛋白(原)降解肽片段,肽6A(50μmol/kg)和RGDS(10μmol/kg)或联合肽6A(25μmol/kg)与RGDS(5μmol/kg)静脉滴注,明显抑制动物的血栓形成,使血浆和血管组织cGMP含量明显增加,肽6A还明显降低血浆纤维蛋白原含量。本工作为肽6A和RGDS作为新型血管再通剂提供了实验依据。
Synthetic fibrinolytic peptide fragments, peptide 6A (50 μmol / kg), and peptide A (50 μmol / kg) were separately pretreated (before thrombosis and after thrombosis) on a model of common carotid artery thrombosis induced by 20% FeCl3 Intravenous instillation of RGDS (10μmol / kg) or combined peptide 6A (25μmol / kg) and RGDS (5μmol / kg) significantly inhibited the thrombosis of animals and significantly increased the content of cGMP in plasma and vascular tissue. Protein content. This work provided an experimental basis for peptide 6A and RGDS as a new revascularization agent.