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大剂量环磷酰胺(CTX)冲击治疗难治性肾病综合征(NS)28例,结果:完全缓解16例,基本缓解5例,部分缓解4例,总有效率84.2％。6项指标治疗前后比较:Ⅰ型的血清蛋白、胆固醇(CH)、尿蛋白定量/24小时均有非常显著性差异(P<0.01、P<0.001、P<0.0001),Ⅱ型的尿蛋白定量/24小时亦有非常显著性差异(P<0.005)。肾功能均无明显差异(P>0.05)。提示Ⅰ型的疗效优于Ⅱ型。副作用以消化道症状及脱发多见。本法具有明显的近期疗效、缓解率高、副作用小、方法简便等优点,在目前不失为一种可取的治疗方法。
High dose cyclophosphamide (CTX) shock treatment of refractory nephrotic syndrome (NS) in 28 cases, the results: complete remission in 16 cases, 5 cases of basic remission, partial remission in 4 cases, the total efficiency of 84.2%. There were significant differences (P <0.01, P <0.001, P <0.0001) in type I serum protein, cholesterol (CH), urinary protein quantitation / 24 hours / 24 hours also had a very significant difference (P <0.005). No significant difference in renal function (P> 0.05). Tip Ⅰ type effect is better than type Ⅱ. Side effects of gastrointestinal symptoms and hair loss more common. This method has obvious short-term curative effect, high remission rate, small side effects, simple method and so on, which is still a preferable treatment method at present.