目的观察鼠神经生长因子对新生儿缺氧缺血性脑病(HIE)的疗效。方法将足月HIE患儿68例随机分为两组,治疗组使用鼠神经生长因子,对照组使用胞二磷胆碱、脑活素治疗,并给予早期干预,生后3 d内做脑电监测,生后1周及生后4周时,分别做头颅CT平扫、脑电监测及新生儿神经行为测定(NBNA)。结果治疗组在头颅CT恢复程度、NBNA测定方面均优于对照组。结论鼠神经生长因子对促进新生儿HIE中枢神经系统功能恢复有明显作用。 Objective To observe the therapeutic effect of murine nerve growth factor on neonatal hypoxic-ischemic encephalopathy (HIE). Methods 68 cases of term HIE children were randomly divided into two groups, the treatment group using the mouse nerve growth factor, the control group with citicoline, cerebrolysin treatment, and give early intervention, 3 days after birth to do EEG Surveillance, 1 week after birth and 4 weeks after birth, respectively, head CT scan, EEG monitoring and neonatal neurobehavioral testing (NBNA). Results In the treatment group, the degree of head CT recovery and NBNA measurement were better than the control group. Conclusion GDNF plays an important role in promoting the recovery of central nervous system function in neonates with HIE.