鸟胺酸脱羧酶抗酶(ornithine decarboxylase antizyme,OAZ)基因通过特殊的阅读框移机制翻译全长有功能的抗酶蛋白,结合并降解鸟氨酸脱羧酶,使细胞内多聚胺浓度下降,抑制细胞增殖。抗酶还能结合cyclinD1,阻滞细胞周期。此外,OAZ还能够引起肿瘤细胞逆分化。它在多种肿瘤细胞中呈低表达,对肿瘤细胞的基因治疗有重要意义。 Ornithine decarboxylase antizyme (OAZ) gene translocates full-length functional anti-enzyme protein through a special reading frame shift mechanism, and binds and degrades ornithine decarboxylase to decrease intracellular polyamines concentration, Inhibit cell proliferation. Anti-enzyme can also bind cyclinD1, blocking the cell cycle. In addition, OAZ can also cause tumor cell dedifferentiation. It is low expression in a variety of tumor cells, gene therapy of tumor cells is of great significance.